Successful applications of a conceptually novel setup of Quantum Field Theory, that accounts for all subtheories of the Standard Model (QED, Electroweak Interaction and Higgs, Yang-Mills and QCD) and beyond (Helicity 2), call for a perspective view in a broader conceptual context. The setting is "autonomous" in the sense of being intrinsically quantum. Its principles are: Hilbert space, Poincar\'e symmetry and causality. Its free quantum fields are obtained from Wigner's unitary representations of the Poincar\'e group, with only physical and observable degrees of freedom. A "quantization" of an "underlying" classical theory is not needed. It allows renormalizable perturbation theory with interactions whose detailed structure, and in some cases even the particle content, is predicted by internal consistency. The results confirm and extend observable predictions for the interactions of the SM without assuming a "principle" of gauge invariance.